About this Research Topic
Chlamydiais a Gram-negative bacteria. The continuous transformation between the two special forms, the infectious elementary body (EB) and the replicative reticulate body (RB), is a unique feature ofChlamydia. It lacks the mechanism to produce metabolic energy and cannot synthesize adenosine triphosphate. This restricts them to intracellular growth, makingChlamydiaan obligatory intracellular bacterium.Chlamydia可引起严重的临床感染。例如,Chlamydiain the genital tract can cause many diseases such as tubal edema, pelvic inflammation and ectopic pregnancy. WhenChlamydiainvades the human body, host cells can initiate innate and adaptive immunity againstChlamydiainfection by recognizing antigens secreted at various stages of the developmental cycle. The pathogenesis ofChlamydiamainly includes its lipopolysaccharides, membrane proteins, plasmid-encoded proteins, and secrete effectors that mediate adhesion and invasion of the host cells.Chlamydiacan regulate the function of host cells to facilitate its intracellular growth and suppress host immune cells to evade the immune system. Although immune and inflammatory responses can help eliminateChlamydiaand reduce host symptoms, there is still a lack of safe and effective vaccines to preventChlamydiainfections at the source.
Chlamydiaoften leads to chronic or even persistent infections, leading to tissue damage or sequelae, such as tubal infertility. However, our understanding of the process of resistance toChlamydiais still very limited. This requires further understanding of howChlamydiainteracts with host cells and eventually leads to diseases. This research topic aims to collect studies on the molecular mechanisms underlying the interaction betweenChlamydiaand its host, which will expand our understanding ofChlamydialpathogenesis and inspire the development of novel therapeutic strategies and vaccines againstChlamydia.
The current Research Topic will focus on, but not be limited to, the following subtopics:
• Virulence factors and pathogenesis ofChlamydia
• Molecular mechanisms of host-Chlamydiainteractions during infection
Chlamydiaoften leads to chronic or even persistent infections, leading to tissue damage or sequelae, such as tubal infertility. However, our understanding of the process of resistance toChlamydiais still very limited. This requires further understanding of howChlamydiainteracts with host cells and eventually leads to diseases. This research topic aims to collect studies on the molecular mechanisms underlying the interaction betweenChlamydiaand its host, which will expand our understanding ofChlamydialpathogenesis and inspire the development of novel therapeutic strategies and vaccines againstChlamydia.
The current Research Topic will focus on, but not be limited to, the following subtopics:
• Virulence factors and pathogenesis ofChlamydia
• Molecular mechanisms of host-Chlamydiainteractions during infection
Keywords: Chlamydia, pathogenic mechanism, immune
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
