Role of Microbes in Ocular Surface Health and Diseases

Microbial communities of the ocular surface play a role in determining both the health and diseases of the ocular surface. The interplay between commensal microorganisms and the ocular surface maintains homeostasis that preserves the ocular surface health and prevents colonization by harmful pathogens. The innate defence arsenal of the ocular surface further helps in defending against pathogens in maintaining eye health. Imbalances in microbial composition cause dysbiosis which is associated with infections and diseases. Invading microbial pathogens can cause serious infections such as keratitis which is vision threatening. Alterations in ocular surface microbiota are also associated with dry eye disease, meibomian gland dysfunction, blepharitis, conjunctivitis, trachoma, and contact lens related infections. The knowledge on involvement of microorganisms in shaping health and diseases of the ocular surface is still evolving.



This research topic seeks to describe the recent advances in understanding the influence of microorganisms in defining homeostasis and pathogenesis of the ocular surface, and the innate antimicrobial defence of the ocular surface. These aspects can aid in holistically evaluating the strengths and vulnerabilities of the ocular surface that may help in designing better approaches for managing ocular surface diseases.



本研究主题邀请研究提供new insights into the role of microorganisms in maintaining health and causing diseases of the ocular surface, and the innate defence of the ocular surface. We welcome Original Research articles, Reviews, Mini-reviews, Systematic reviews, Technology Reports and Research Reports that involve, but not limited to, the following themes:



Functions of ocular surface microbes

Microbiota in ocular surface health

Effectors of innate host defence and evasion

Altered microbiota in ocular surface diseases

Microbial infections of the ocular surface

Infection/defence using OMICS approaches involving host, microbe, or both

Keywords: ocular surface microbiota, ocular surface infections, ocular surface health, innate ocular defence, ocular surface homeostasis

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